Molecular Basis of Life - Herbsttagung der GBM

GBM Fall Conference 2022
"Molecular Basis of Life"

Heinrich Heine University Düsseldorf
September 14 - 16, 2022

Welcome

Dear Friends and Colleagues,

we’d like to invite you to participate in the Fall Conference of the German Society for Biochemistry and Molecular Biology (GBM) "Molecular Basis of Life" at the Heinrich Heine University Düsseldorf, which will take place in September 14th – 16th, 2022.

The conference is organized by Prof. Dr. Claus Seidel (Heinrich Heine University) in collaboration with several GBM study groups.

This meeting is intended to promote lively discussions at the crossroads of various fields of biochemistry such as biophysics, structural biology, bioenergetics, cell biology, bioinformatics and others.

We look forward to your visit and an inspiring meeting!

Claus Seidel & Lutz Schmitt
(Heads of the Organizing Committee)

all the way up

Programm

Your Contribution

38 short presentations will be selected from the submitted abstracts. There will also be two poster sessions.

Present your research in a short talk or on a poster and submit your abstract here.
(->Guidelines for abstract submission)

Registration & Abstract Submission

Further Contributions

26 Invited talks:
- 5 Prize lectures - 9 Plenary speakers
- 12 Top speakers

5 Prize lectures:
     - Otto Warburg Medal
     - Fritz Lipmann Lecture
     - PicoQuant Young Investigator Award
     - Biomol PhD Award - Nikon PostDoc Award

Topics & Top Speakers

Biomolecules and their assemblies: from structure and dynamics to function

Andrea Musacchio /Dortmund [DE] — Andrea Musacchio

(Bio)chemical approaches to manipulate protein

Energy for life - principles and diversity of biological energy conversion

Johannes Messinger /Uppsala [SE] — Johannes Messinger

Biophysical chemistry and cell biology of interfaces and functional phase separation

Dorothee Dormann /Mainz [DE] — Dorothee Dormann

Computational biophysics and biology

Imaging molecules of life

Jörg Bewersdorf /New Haven [USA] — Jörg Bewersdorf

New technologies for molecules in Life Science

Peter Rehling /Göttingen [DE] — Peter Rehling

Cell biology meets systems and synthetic biology

Tanja Kortemme /San Francisco [USA] — Tanja Kortemme

Signal transduction and diseases

Felix Randow /Cambridge [UK] — Felix Randow

Structure-function-relationships regulating signaling events

Supramolecular chemistry on proteins

Multiscale biochemistry of membranes and membrane proteins

Christos Gatsogiannis /Münster [DE] — Christos Gatsogiannis

New & Notable

Prize Lectures

Otto Warburg Medal

Petra Schwille /München [DE] — Petra Schwille

The German Society for Biochemistry and Molecular Biology e.V. and Elsevier/BBA awards Petra Schwille in recognition of her pioneering work in the field of molecular biophysics the Otto Warburg Medal.

Lecture: Sept. 16, 14:00

Fritz Lipmann Lecture

Monika Fuxreiter /Padova [IT] — Monika Fuxreiter

The Society for Biochemistry and Molecular Biology e.V. honors Monika Fuxreiter with the Fritz Lipmann Lecture. The Lecture is named after the famous biochemist Fritz Lipmann.

Lecture: Sept. 15, 09:40

Picoquant Young Investigator Award

Johannes Broichhagen /Berlin [DE] — Johannes Broichhagen

We thank PicoQuant for the kind support!

Lecture: Sept. 15, 14:25

Biomol PhD Award

Zhexin Wang /Dortmund [DE] — Zhexin Wang

We thank Biomol for the kind support!

Lecture: Sept. 15, 15:05

Nikon PostDoc Award

We thank Nikon for the kind support!

Lecture: Sept. 15, 15:25

Program - Wednesday, Sept. 14

08:45 - 09:00

Opening (by the conference president Claus Seidel)

09:00 - 09:40

Plenary Session 1 (Chair: J.R. Weir)
Johannes Messinger /Uppsala [SE]
Picturing biological water oxidation by snapshot crystallography

09:40 - 10:20

Plenary Session 1 (Chair: J.R. Weir)
Tanja Kortemme / San Francisco [USA]
The allosteric landscape of a fundamental molecular switch

10:20 - 10:50

Coffee break

10:50 - 12:30

Parallel Sessions 1

Cell biology meets systems and synthetic biology (1A) (Chair: M. Zurbriggen)
10:50 Roman Jerala /Ljubliana [SI] Coiled-coil modules for designed molecular and cellular logic circuits
11:20 Aránzazu del Campo /Saarbrücken [DE] Living therapeutic devices: on-demand drug production and delivery in your body
11:50 Alena Khmelinskaia /Bonn [DE] Expanding the repertoire of de novo protein assemblies

Energy for life - principles and diversity of biological energy conversion (1B) (Chair: V. Zickermann)
10:50 Ulrich Brandt /Nijmegen [NL] Mitochondrial complex I: evolution, assembly and mechanism
11:15 (short talk) Anna Frank /Bochum [DE] Rational design of biophotoelectrodes for in vitro biocatalysis
11:30 (short talk) Wei-Chun Kao /Freiburg [DE] Cryo-EM structure of the actinobacterial respiratory supercomplex: an efficient generator and potential drug target
11:45 (short talk) Ingrid Span /Erlangen [DE] Structural insights into the catalysis of the [FeFe] hydrogenase from Desulfovibrio desulfuricans
12:00 (short talk) Georg Reiser /Magdeburg [DE] Recent uncovered protective strategies in neurons against lipotoxicity in brain, an organ with very high fat content, rapid ATP turnover and large oxygen consumption
12:15 (short talk) Jan Lambertz /Bochum [DE] Isolation of three different Photosystem II complexes from Thermosynechococcus elongatus via Strep-tagged PsbO

Structure-function-relationships regulating signaling events (redox) (1C) (Chair: G. Poschmann & C. Berndt)
10:50 Kai Tittmann /Göttingen [DE] Lysine-cysteine redox switches in proteins
11:15 (short talk) Michael Lammers /Greifswald [DE] Post-translational lysine acetylation regulates the transcriptional regulator RutR as shown by using a structural biological and synthetic biological approach
11:30 (short talk)Kathrin Ulrich /Göttingen [DE] Redox-regulated chaperones in cell stress responses
11:45 (short talk) Johannes Eble /Münster [DE] A redox-dependent thiol-switch and a Ca2+ binding site within the hinge region hierarchically depend on each other in α7β1 integrin regulation
12:00 (short talk) Marie-T. Hopp /Bonn [DE] Molecular basis of heme-driven pathway activation in hemolytic disorders
12:15 (short talk) Bianca Axinte /Düsseldorf [DE] Interplay of inositol pyrophosphate pathway and iron-sulfur cluster biogenesis

12:30 - 14:20

Lunch & Workshops

12:30 - 13:00 (Industrial Symposium)
Nike Bahlmann /BioEcho Life Sciences, Köln [DE]
One-step purification of nucleic acids – Shorten time to result and be more sustainable with EchoLUTION

12:50 - 13:35 (Industrial Symposium)
Taravat Saeb Gilani /Becker & Hickl, Berlin [DE]
How to Employ Metabolic Imaging for Cancer Research: A Tutorial“

13:05 - 13:35 (Industrial Symposium)
Ruben Prange /QIAGEN, Hilden [DE]
Digital PCR - The fully automated solution for absolute PCR precision

13:40 - 14:10 (Industrial Symposium)
Christian Börnchen /Nikon, Düsseldorf [DE]
Deep-learning assisted data processing and workflows using Nikon Imaging Software (NIS-Elements)

14:20 - 15:00

Plenary Session 2 (Chair: I. Koch)
Christos Gatsogiannis /Münster [DE]
Good things come to those who bait: docking and recycling at the peroxisomal membrane

15:00 - 15:40

Plenary Session 2 (Chair: I. Koch)
Edda Klipp /Berlin[DE]
Single cell transcription during yeast cell cycle

15:50- 17:00

Parallel Sessions 2

Multiscale biochemistry of membranes and membrane proteins (2A) (Chair: L. Schmitt)
15:50 Uris Lianne Ros Quincoces /Köln [DE] Shedding light on the regulation and execution of necroptosis
16:15 (short talk) Fabio Lolicato /Heidelberg [DE] Cholesterol promotes head group visibility and clustering of PI(4,5)P2 driving unconventional secretion of Fibroblast Growth Factor 2
16:30 (short talk) Marta Gozzi /Leipzig [DE] On the Road to Finding the Right Key: Structural Characterisation of Three Active States of the Human Neuropeptide Y Type 4 Receptor (hY4R) at the Molecular Level
16:45 (short talk) Andreas Diepold /Marburg [DE] The dynamic exchange of core components of the type III secretion system shapes its assembly and function

Computational biophysics and biology (2B) (Chair: C. Hunte)
15:50 Birgit Strodel /Düsseldorf [DE] Effects of in vivo conditions on protein aggregation: computational approaches
16:15 (short talk) Till Rudack /Bochum [DE] A scale‑spanning integrative modeling strategy to study structure, dynamics, and function of complex molecular machines
16:30 (short talk) Hans-Joachim Wieden /Winnipeg [CA] Exploiting the intrinsic structural dynamics of biomolecules as design feature - from antimicrobials to novel biosensors
16:45 (short talk) Mohsen Sadeghi /Berlin [DE] Dynamic framework for large-scale modeling of biomembranes and flexible peripheral proteins

from 17:00 on

Poster Session I (even numbers) and Get togather at the Posters with pretzels, wine & beer

Program - Thursday, Sept. 15

09:00 - 09:40

Plenary Session 3 (Chair: V. Haucke)
Felix Randow /Cambridge [UK]
How cells defend their cytosol against bacteria: LPS ubiquitylation and other tricks

09:40 - 10:25

Fritz Lipmann Lecture (Laudatio: C. Seidel):
Monika Fuxreiter /Padova [IT]
The fundamental nature of the droplet state of proteins

10:25 - 10:55

Coffee break

10:55 - 12:15

Parallel Sessions 3

Supramolecular chemistry on proteins (3A) (Chair: P. Bayer)
10:55 Shirley Knauer /Essen [DE] Exploiting supramolecular chemistry to modulate protein function
11:20 (short talk) Bianca Emma Kamba /Essen [DE] Catch Me if You Can - Entrapment of Methylated Arginine by Supramolecular Hosts
11:35 (short talk) Ulla Gerling-Driessen /Düsseldorf [DE] Multi-TaG: Next generation bioorthogonal probes for multi-method targeted analysis of glycoproteins
11:50 (short talk) Hajo Kries /Jena [DE] Engineering DNA-templated nonribosomal peptide synthetase

Signal transduction and diseases (3B) (Chair: C. Monzel)
10:55 Margret Bülow /Bonn [DE] Organelle communication in neuron function and physiology
11:20 (short talk) Antje Ebert /Göttingen [DE] Altered cytoskeleton signaling in cardiac disease determines defective cellular cargo internalization
11:35 (short talk) Jan Bröckel /Kassel [DE] Direct Interaction of Smoothened and PKA Opens Up a New Window into Hedgehog Signaling
11:50 (short talk) Linlin Lei /Bochum [DE] A possible role of the ubiquitin kinase PINK1 in protein quality control

New & Notable Session (3C) (Chair: J. Lassak)
10:55 Andrea Thorn /Hamburg [DE] What 2000 macromolecular structures tell us about SARS-CoV-2
11:20 Daniel Huster /Leipzig [DE] Rhomboid-Catalyzed Intramembrane Proteolysis Requires Hydrophobic Matching with the Surrounding Lipid Bilayer
11:45 Oleg Sitsel /Dortmund [DE] The unusual secretion mechanism of Tc toxins

12:15 - 13:45

Lunch & Workshops

12:30 (Industrial Symposium)
Evangelos Sisamakis /PicoQuant, Berlin [DE]
Fluorescence-based studies of molecules with Luminosa: from dynamic stuctural information via single-molecule FRET to studying molecular interactions in the cell

13:05 (Industrial Symposium)
Roman Renger /LUMICKS Technologies, Amsterdam [NL]
Towards Single Molecule Biology using Optical Tweezers and Fluorescence Microscopy

13:45 - 14:25

Plenary Session 4 (Chair: K. Winklhofer)
Jörg Bewersdorf /New Haven [USA]
All-optical Super-resolution Imaging of Molecules in Their Nanoscale Cellular Context

14:25 - 15:05

Picoquant Young Investigator Award:
Johannes Broichhagen
Visualizing and Manipulating Cell Surface Proteins

15:05 - 15:25

Biomol PhD Award:
Zhexin Wang
Structural insights into sarcomere organisation by cryo-electron tomography

15:25 - 15:45

Nikon PostDoc Award:
Khaled Selim
Cross-talk between cAMP and c-di-AMP signaling via carbon sensor protein SbtB: Linking CO2 homeostasis with diurnal metabolic switch

15:45 - 16:15

Coffee break

16:15 - 17:40

Parallel Sessions 4

Imaging molecules of life (4A) (Chair: M. Bülow)
16:15 Cornelia Monzel /Düsseldorf [DE] Elucidating Receptor Oligomerization States in CD95 Signaling with Super-Resolution and Multiparametric Image Spectroscopy
16:40 (short talk) Max Halupczok /Bochum [DE] Arctic TREx – Combining Cryofixation with Ten-fold Robust Expansion Microscopy to Image Neural Cells
16:55 (short talk) Gavin Rice /Dortmund [DE] TomoTwin: Generalized 3D localization of macromolecules in cryo-electron tomograms
17:10 (short talk) Tejal Patwari /Bonn [DE] OptoRiboGenetics: Light-dependent Control of RNA function through PAL-RNA platform
17:25 (short talk) Sofia Elizarova /Göttingen [DE] A fluorescent nanosensor paint detects dopamine release at axonal varicosities with high spatiotemporal resolution

New technologies for molecules in Life Sciences (Analytics) (4B) (Chair: Y. Reinders)
16:15 Prasad Phapale /Dortmund [DE] Spatial metabolomics technology for life science and medicine
16:40 (short talk) Clara Correia-Melo /Berlin [DE] Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespan
16:55 (short talk) Stephan Riesenberg /Leipzig [DE] Highly efficient stem cell genome editing to study the genetic basis of modern humans and disease-relevant mutations
17:10 (short talk) Ronay Cetin /Frankfurt [DE] Sequential genetic dependencies identified by time-resolved orthogonal gene editing
17:25 (short talk) Nicolaas van der Voort /Düsseldorf [DE] To unlock sensitive molecular switches in live cells using high throughput FRET

(Bio)chemical Approaches to manipulate proteins (4C) (Chair: F. Hausch)
16:15 Henning Mootz /Münster [DE] Manipulating and Labeling of Proteins by Selectively Addressable Thiol Moieties
16:40 Katja Klausz /Kiel [DE] Bispecific NK Cell Engagers Activating NK Cells via NKp30 to Improve Tumor Cell Lysis and Pro-Inflammatory Cytokine Release
17:00 Sebastian Pomplun /Leiden [NL] Engineering Bioactive Dimeric Transcription Factor Analogs via Flow Synthesis and Palladium Rebound Mediated Protein Cross-Coupling
17:20 Martin Empting /Saarbrücken [DE] Blocking bacterial pathogenicity by novel quorum sensing inhibitors for the treatment of chronic Pseudomonas aeruginosa infections

17:40 - 19:15

Poster Session II (odd numbers)

19:30 - 23:00

Social Event in the foyer at the venue with fingerfood

Program - Friday, Sept. 16

09:00 - 09:40

Plenary Session 5 (Chair: S. Korn)
Andrea Musacchio /Dortmund [DE]
The kinetochore: an intrinsically divisive molecular machine

09:40 - 10:20

Plenary Session 5 (Chair: S. Korn)
Peter Rehling / Göttingen [DE]
Regulating mitochondrial protein biogenesis

10:20 - 10:45

Coffee break

10:45 - 12:35

Parallel Sessions 5

Biomolecules and their assemblies: from structure and dynamics to function (Proteins and RNA) (5A) (Chair: S. Raunser)
10:45 Manuel Etzkorn /Düsseldorf [DE] Exploring the Dynamic World of Membrane Systems and Biocatalysis
11:10 Ingrid Tessmer /Würzburg [DE] Interactions between DNA repair and transcription
11:35 (short talk) Sandra Schlee /Regensburg [DE] Relation between loop motion and catalytic activity by the example of the (βα)8-barrel enzyme HisF
11:50 (short talk) Nils-Alexander Lakomek /Düsseldorf [DE] Structural dynamics of the intrinsically disordered SNARE proteins at the membrane interface: Recent insights by a combined solution and solid-state NMR approach
12:05 (short talk) Hauke Hillen /Göttingen [DE] Cutting RNA to power life: Molecular basis of RNA processing in human mitochondria
12:20 (short talk) Julian Folz /Düsseldorf [DE] FRET measurements resolving structures, dynamics and transitions of various biomolecules

Biophysical chemistry and cell biology of interfaces and functional phase separation (5B) (Chair: Ch. Herrmann)
10:45 Titus Franzmann /Dresden [DE] Molecular mechanisms of macromolecular assembly during cellular stress responses
11:10 Christoph Weber /Augsburg [DE] Interplay between phase separation and reversible aggregationTitle to be announced
11:35 (short talk) Felix Müller-Planitz /Dresden [DE] Chromatin remodeling in condensed and phase separated chromatin
11:50 (short talk) Dmitry Shvarev /Osnabrück [DE] Structure of the lysosomal membrane fusion machinery
12:05 (short talk) Wolfgang Hoyer /Düsseldorf [DE] Metastable amyloid-β oligomers – Kinetics, mechanisms, interactions
12:20 (short talk) Peter Hemmerich /Jena [DE] Mechanism of SUMO-mediated phase separation at PML nuclear bodies

12:35 - 13:20

Lunch

13:20 - 14:00

Plenary Session 6 (Chair: B. Schwappach-Pignataro)
Dorothee Dormann /Mainz [DE]
Control of aberrant phase transitions in neurodegenerative diseases

14:00 - 14:55

Otto Warburg Medal (Laudatio: C. Seidel, Welcome: J. D'Angelor (Elsevier/BBA)):
Petra Schwille /Martinsried [DE]
Life as a matter of function

14:55 - 15:00

Poster awards & Closing remarks

Download Program (pdf)

Download Abstracts (pdf)

Stairway to heaven

Registration

Deadlines:
Late abstracts for your contribution are further welcome.
The short talks (38 slots) will be selected from the submitted abstracts until July 24.

Moreover, we intent to organize an additional session "New & Notable" for very latest research.
All contributions submitted by 28.8. will be considered for this session.

The contributions that were not selected for a short presentation and also not rejected are scheduled for the poster sessions.

Please submit your abstract as early as possible to help us organize the program and poster session

Please email your abstracts additionally to the head of the scientific committee Claus Seidel (cseidel@hhu.de).

Registration Fee for Members*

Members*	before June 15	as of June 15	on site
Academia/ from Industry	320 €	370 €	400 €
PhD student	175 €	200 €	220 €
Bachelor/ Master student	75 €	90 €	105 €
Retiree	75 €	90 €	105 €

Registration Fee

Non-Members*	before June 15	as of June 15	on site
Academia/ from Industry	370 €	420 €	450 €
PhD student	185 €	210 €	230 €
Bachelor/ Master student	85 €	100 €	115 €
Retiree	85 €	100 €	115 €

* member of the GBM, DECHEMA, DGZ, GDCh, VAAM, Bunsen Society
(With a proof of your membership)

Registration fees include admission, conference materials, coffee breaks and Pretzels with beer, wine and non-alcoholic drinks during the Get together on Wednesday.
A small fee will be charged for the conference dinner. All registered participants will be informed about this in detail by email.

Participants are expected to book and pay for their own accommodation and travel expenses.

Registration & Abstract Submission